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. Author manuscript; available in PMC: 2022 Sep 6.
Published in final edited form as: Mol Cancer Res. 2022 Sep 2;20(9):1365–1378. doi: 10.1158/1541-7786.MCR-21-1018

Figure 5. Environmental conditions that promote the selection of PPM1D mutants in the blood and esophageal lining.

Figure 5.

Schematic representation of how premalignant clonal expansion of PPM1D mutants in the blood and esophagus is shaped by multiple environmental stressors. These stressors can have a positive, neutral, negative effect on PPM1D mutant clonal dynamics.