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. Author manuscript; available in PMC: 2022 Dec 30.
Published in final edited form as: Am J Transplant. 2022 Jun 15;22(10):2306–2322. doi: 10.1111/ajt.17116

Figure 4. Ischemia Reperfusion Injury, MCMV infection, and allogeneic transplantation each contribute to intragraft Th17 cell infiltration.

Figure 4.

(A) Syngeneic transplantation was performed using D−R− and D+R+ grafts to evaluate role of ischemia-reperfusion injury (IRI) without alloimmune responses. (B) CCL20 and CXCL10 quantities in D−R− and D+R+ syngeneic transplants. (C) Frequencies of Th17 infiltrates in syngeneic D−R− and D+R+ grafts. (D) Intragraft Th17 cells co-expressing IFN-γ and/or TNF-α in D−R− and D+R+ grafts. (E) Percentage and proportions of single or multiple cytokines expressing Th17 cells in syngeneic and allogeneic grafts. For (A-D), data are represented as mean ± standard deviation (SD) and are analyzed by two- sided Student’s t-test. For (E), mean values are shown.