Skip to main content
. Author manuscript; available in PMC: 2022 Sep 6.
Published in final edited form as: Clin Cancer Res. 2022 Sep 1;28(17):3742–3751. doi: 10.1158/1078-0432.CCR-22-0203

FIGURE 1: Homology Directed Repair (HDR) assay evaluation of clinically observed BRCA2 DNA binding domain (DBD) missense variants.

FIGURE 1:

HDR scores with 95% confidence intervals (CI) are presented on a 1 to 5 scale based on HDR activity of wild type BRCA2 (HDR score=5) and the p.Asp2723His non-functional pathogenic variant (HDR score=1). HDR thresholds for functional (>2.50) and non-functional (<1.49) are indicated by horizontal dotted lines. Variants are ordered based on amino acid position (x-axis).