Figure 1.

The AR cistrome is reprogrammed in prostate tumorigenesis in AA men. a) Unsupervised pairwise correlation of the AR cistromes from AA prostate tumor and normal specimens. Hierarchical clustering demonstrates the relatedness of each AR cistrome. b) Volcano plot of AR binding sites enriched in AA tumor versus normal specimens (T-ARBS; N = 28,810) and normal versus tumor specimens (N-ARBS; N = 11,736) with an FDR-adjusted p-value < 0.01 and log2 fold-change > 1. c) MSigDB perturbation pathways enriched in the 28,810 T-ARBS using the GREAT tool.(22)