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. Author manuscript; available in PMC: 2022 Nov 27.
Published in final edited form as: Cancer Res. 2022 Aug 16;82(16):2848–2859. doi: 10.1158/0008-5472.CAN-21-3552

Figure 2.

Figure 2.

Differences in the PCa AR cistrome between AA and EA men associate with distinct RNA expression programs. a) Unsupervised pairwise correlation of the AR cistromes from AA and EA prostate tumors. Hierarchical clustering demonstrates the relatedness of each AR cistrome. b) Volcano plot of ancestry-enriched AR binding sites (ARBS). 16,678 ARBS were enriched in AA relative to EA (AA-ARBS) prostate tumors and 1,655 ARBS in EA relative to AA prostate tumors (EA-ARBS) with an FDR-adjusted p-value < 0.01 and log2 fold-change > 1. c) Differential gene expression analysis of 30 AA and 19 EA paired tumor-normal prostate specimens. 466 genes were upregulated in AA and 729 genes were upregulated in EA prostate tumors with an FDR-adjusted p-value < 0.05 and log2 fold-change > 1.5. d) GSEA of AA-ARBS are enriched for genes upregulated in AA relative to EA prostate tumors (normalized enrichment score [NES] = 1.96; P < 0.001). e) GSEA of genes upregulated in AA prostate tumors are enriched for AA-ARBS (NES = 2.04; P < 0.001).