Skip to main content
. Author manuscript; available in PMC: 2022 Nov 27.
Published in final edited form as: Cancer Res. 2022 Aug 16;82(16):2848–2859. doi: 10.1158/0008-5472.CAN-21-3552

Figure 5.

Figure 5.

Upregulated lipid metabolism is associated with worse prostate cancer outcomes. Kaplan-Meier survival curves for time to treatment failure (a) and overall survival (b) on abiraterone or enzalutamide for 81 men with metastatic castration-resistant PCa based on lipid metabolism activity.(36) Lipid metabolism scores were generated by applying ssGSEA to normalized RNA-seq data and extracting sample-level enrichment scores for the Hallmark Fatty Acid Metabolism gene set. Outcomes were compared between men in the top quartile versus the lower three quartiles based on ssGSEA enrichment scores.