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. Author manuscript; available in PMC: 2022 Dec 30.
Published in final edited form as: Br J Pharmacol. 2022 Jul 24;179(20):4829–4843. doi: 10.1111/bph.15915

Figure 2: A GA optimized a VC protocol to isolate individual current contributions in an in silico iPSC-CM model.

Figure 2:

A, The GA was used to develop individual VC protocols for seven of the most predominant ionic currents in cardiac cells. B, These seven protocols were systematically shortened and joined together by a −80mV holding step to produce an optimized VC protocol that isolates each of the seven currents.