Table 1:

Substrates of ADAM17

Cytokines	Receptors	Adhesion molecules
CD44 [117]   CX3CL1 [252,253]   FLT-3L [254]   Jagged 1 [38]   Kit-ligand 1 and 2 [255]   LAG-3 [256]   MICA [257]   MICB [258]   RANKL [259]   TNF-α [20,260,190,261,4,11]   TNF beta [262]	ACE2 [263–265]   APOER [266]   CD30 [267]   CD40 [268]   CD89 [269]   EMMPRIN [135]   EPCR [83]   Ephrin B4 [135]   ErbB4 [270,271]   GHR [272,273]   GPIba [274]   GPV [275]   GPVI [276]   IL-1R II [21]   IL-6R [277,278]   Integrin beta-1 [150]   Leptin receptor [279]   LOX-1 [280]   M6P/IGF2R [281]   Notch1 [282,283]   NPR [284]   p55 TNF alpha RI [20,21]   P75 TNF receptor [113]   p75NTR [285,21]   Ptprz [286]   syndecan 1 and 4 [287]   Toll-like receptor 4 [288]   TrkA [289]   VEGFR [31]   VPS10p [290]	ALCAM [291]   CD44 [198,117]   CD62L [292]   collagen XVII [293]   desmoglein-2 [291]   EpCAM [294]   ICAM-1 [111]   JAM-A [123]   L-selectin [113]   L1-CAM [295]   PTP-LAR [296]   NCAM [297]   nectin-4 [298]   PECAM-1 [135]   VCAM-1 [109,299]
Growth factors		Others
Amphiregulin [300,190,301]   CSF-1 [138]   Epigen [302]   Epiregulin [190]   HB-EGF [135,300,190,303]   IGFR1 [135]   Neuregulin-1 [199]   Pref-1 [282,304]   SEMA4D [305,306]   TGF alpha [113,300]   Tomoegulin-2 [307]	APP [308,309]   CD163 [310]   KIM-1 [311]   Klotho [312]   MerTK [313]   PMEL17 [314]   PrPc [315]   Tim-3 [316]   VASN [317]