Table 2:
Cardiovascular related substrates of ADAMs
| inflammation | angiogenesis | Proliferation/Migration | others | |
|---|---|---|---|---|
| ADAM8 | CD16 [318] CD23 [319] CX3CL1 [318] L-selectin [320] TNF alpha [318] TNFR1 [321] VCAM-1 [322] |
TGF alpha [318] | ||
| ADAM9 | CD40 [210] VCAM-1 [210] |
Notch [282] Tie-2 [210] VE-cadherin [210] VEGFRII [210] |
HB-EGF [323] | ADAM10 [324,325] EphB4 [210] |
| ADAM10 | CD44 [117] CX3CL1 [181] CXCL16 [182] IL-6R [183] RAGE [184] TNF alpha [185] |
E-cadherin [326] JAM-A [123] N-cadoherin [221] Notch1 [186,282] Notch2 [327] NRP-1 [31] VEGFRII [188] VE-cadherin [189] |
Betacellulin [190,191] HB-EGF [63] |
CD84 [328] Corin [195] DDR1 [193] Klotho [109] Meprin A [196] Neuregulin [329] RANKL [194] |
| ADAM12 | E-cadherin [330] IFGBP3 [331] IFGBP5 [331] Notch1 [282] |
Betacellulin [332] HB-EGF [333] |
||
| ADAM15 | E-caderin [334] VEGFR [335] |
FGFR2iiib [331] | ADAM10 [325] | |
| ADAM17 | CD40 [268] CD44 [117] CD163 [310] CX3CL1 [252,253] ICAM-1 [111] IL-1R II [21] IL-6R [277,278] L-selectin [113] L1-CAM [295] p55 TNF alpha RI [20,21] P75 TNF receptor [113,21] PECAM-1 [135] TNF alpha [20,260,190,261,4,11] VCAM-1 [109,299] |
JAM-A [123] Notch1 [283,282] VEGFR [31] |
HB-EGF [135,300,190,303] IGFR1 [135] Pref-1 [282,304] SEMA4D [305] syndecan 1 and 4 [287] TGF alpha [113,300] |
ACE2 [263–265] EPCR [83] Ephrin B4 [135] Jagged 1 [38] Klotho [312] RANKL [259] |
| ADAM19 | Alpha 2 macroglobulin [336] TNF alpha [337,20] |
Neuregulin [338,231] | (pro)renin receptor [339] RANKL [337] |
|
| ADAM28 | TNF alpha [234] | IGFBP3 [340] | CTGF [341] | vWF [342] |
| ADAM33 | RANKL [343] |