Table 3.
Tumor Response, Surgical Outcome, Pathological Response and Chemotherapy Response Score with NAC/GEN-1 escalating doses.
| Radiographic Response | Total (n) | Cohort 1 36 mg/m2 |
Cohort 2 47 mg/m2 |
Cohort 3 61 mg/m2 |
Cohort 4 79 mg/m2 |
|
|---|---|---|---|---|---|---|
| Tumor Response | CR | 2 | 1 | 0 | 0 | 1 |
| PR | 10 | 0 | 3 | 3 | 4 | |
| SD | 2 | 2 | 0 | 0 | 0 | |
| Objective Response Rate | 67% | 100% | ||||
| Surgical Outcome | R0 | 9 | 2 | 0 | 2 | 5 |
| R1 | 3 | 1 | 2 | 0 | 0 | |
| R2 | 2 | 0 | 1 | 1 | 0 | |
| R0 Resection Rate | 33% | 88% | ||||
| Pathological Response | cPR | 1 | 1 | 0 | 0 | 0 |
| Micro | 8 | 1 | 2 | 1 | 4 | |
| Macro | 5 | 1 | 1 | 2 | 1 | |
| cPR/Micro Rate | 60% | 63% | ||||
| Chemotherapy Response Score | CRS 3 | 5 | 1 | 0 | 2 | 2 |
| CRS 2 | 5 | 2 | 1 | 0 | 2 | |
| CRS 1 | 4 | 0 | 2 | 1 | 1 | |
| CRS 3 Rate | 17% | 50% | ||||