Table 2:

Univariable and Multivariable Cox Regression Analysis Investigating Impact of Demographic, Clinical, and Tumor Characteristics on Overall Survival in Patients with BCLC B- or C-Stage Disease

	Univariable Analysis		Multivariable Analysis
Variable	Hazard Ratio	P Value	Hazard Ratio	P Value
Age	1.01 (1.00, 1.02)	.001	1.01 (1.00, 1.02)	.03
Sex	0.8 (0.60, 1.00)	.11	0.8 (0.62, 1.12)	.23
Race and ethnicity	1.14 (0.86, 1.5)	.8	0.95 (0.7, 1.3)	.76
Cause of cancer	0.9 (0.69, 1.16)	.41	1.14 (0.8, 1.61)	.45
Child-Pugh class
A vs B	0.54 (0.44, 0.66)	<.001	1.77 (1.42, 2.19)	<.001
A vs C	0.60 (0.38, 0.93)	.02	3.45 (2.20, 5.44)	<.001
ECOG performance status (0 vs >0)	0.53 (0.44, 0.66)	<.001	0.64 (0.52, 0.79)	<.001
AFP ≥400 ng/dL	0.47 (0.35, 0.61)	<.001	1.6 (1.2, 2.1)	.004
Posttreatment with sorafenib	0.45 (0.06, 3.2)	.44	0.13 (0.01, 2.34)	.17
Tumor characteristics
Lobar distribution	0.37 (0.30, 0.45)	<.001	1.69 (1.28, 2.23)	<.001
Tumor multiplicity	0.53 (0.42, 0.67)	<.001	0.86 (0.64, 1.15)	.31
Extrahepatic metastasis	0.37 (0.28, 0.48)	<.001	1.95 (1.47, 2.56)	<.001
TTV	2.2 (1.8, 2.9)	<.001	1.2 (0.9, 1.5)	.16
ETV ≥65 cm3	2.5 (2.0, 3.0)	<.001	2.00 (1.54, 2.61)	<.001
ETB ≥4%	2.5 (2.0, 3.1)	<.001	16 (2.7, 91)	<.001

Note.—Data in parentheses are 95% CIs. The adjusted multivariable analysis included the parameters that were statistically significantly associated with overall survival from among the following covariates: age, Child-Pugh class, Eastern Cooperative Oncology Group (ECOG) performance status, α-fetoprotein (AFP) level, lobar distribution, and extrahepatic metastasis as well as total tumor volume (TTV), enhancing tumor volume (ETV), and enhancing tumor burden (ETB).