. Author manuscript; available in PMC: 2022 Aug 9.

Published in final edited form as: Med. 2022 Aug 8;3(10):705–721.e11. doi: 10.1016/j.medj.2022.08.002

Table 1. Binding of various neutralizing antibodies to SARS-CoV-2 and select VOC.

Omicron spike S1 binding affinity to indicated nAbs.

Binding Affinity to Spike S1 Omicron (BA.1)
Reference clone nAb	ka (1/Ms)	kd (1/s)	KD (M)	Rmax (RU)	Chi² (RU²)
STI-9167	1.99 E+05 ± 1.16 E+04	4.5 E−03 ± 1.00 E−04	2.26 E−08 ± 8.50 E−10	104.6 ± 5.0	0.22 ± 0.02
COV2-2130	1.06 E+05 ± 8.05 E+04	2.28 E−02 ± 9.69 E−03	2.5 E−07 ± 7.67 E−08	59.8 ± 16.4	0.1 ± 0.05
COV2-2196	n.d.	n.d.	n.d.	n.d.	n.d.
S309	1.62 E+04 ± 1.01 E+03	3.95 E−04 ± 1.53 E−05	2.45 E−08 ± 2.38 E−09	63.9 ± 7.2	0.01 ± 0.01
COV2-2130 + COV2-2196	n.d.	n.d.	n.d.	n.d.	n.d.
LY-CoV1404	7.92 E+04 ± 5.92 E+03	6.77 E−03 ± 5.15 E−04	8.55 E−08 ± 2.38 E−09	179 ± 11.7	0.05 ± 0.01

Abbreviation: n.d. not determined