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. Author manuscript; available in PMC: 2022 Oct 14.
Published in final edited form as: FASEB J. 2022 Oct;36(10):e22514. doi: 10.1096/fj.202200765R

Figure 6: Ceramide Synthase 6 (CERS6) overexpression increases C16 ceramide generation in CNL treated MOLM-14 cells, leading to augmented cell death in the presence of Ara-C and/or venetoclax.

Figure 6:

A: Ceramide levels from MOLM-14 cells transduced with a control vector or CERS6 for overexpression and treated with Vehicle or CNL 15μM for 24 hours. N = 5; shown are means +/− S.E.M. *p<0.001 to vector, # p<0.036 vs. CERS6, $, p<0.03 vs. vector+CNL. Insert shows expression of FLAG-CERS6 and β-actin. B: Cell death was assessed in control or CERS5 or CERS6 overexpressing MOLM-14 treated with the indicated drug combinations (CNL 15μM, Ara-C 1.25μM, venetoclax 50nM) for 24 hours. N = 5; shown are means +/− S.E.M. *, p<0.05 between control vector and CERS5 or control vector and CERS6 overexpression in each treatment group.