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. Author manuscript; available in PMC: 2022 Oct 13.
Published in final edited form as: Sci Immunol. 2022 Oct 28;7(76):eabp9962. doi: 10.1126/sciimmunol.abp9962

Fig. 6. Humanization of SW186.

Fig. 6.

(A) Illustration of mouse antibody humanization strategy. (B) The kinetics of humanized SW186 (H2L3) binding to the spike protein using BLI. The KD value is mean ± SD, n=3. (C) This heatmap summarizes the mean KD values of humanized SW186 antibodies binding to the spike protein of SARS-CoV-2 (Wuhan-hu-1 strain) as measured by BLI. The binding kinetic parameters are summarized in table S4. (D) Neutralization activities (IC50 at ng/mL) of humanized antibodies against SARS-CoV-2 Delta pseudovirus. Antibodies were serially diluted 1:3 from 30 μg/mL for 7 dilutions, with each dilution in duplicate.