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. Author manuscript; available in PMC: 2023 Jan 5.
Published in final edited form as: Cancer Discov. 2022 Nov 2;12(11):2586–2605. doi: 10.1158/2159-8290.CD-22-0200

Fig 5: Proteogenomic features associated with LIG1.

Fig 5:

Heatmap showing copy number, mRNA and protein levels of LIG1, which are significantly (Wilcoxon rank sum test) lower (blue) in non-pCR tumors. Corresponding boxplots show that tumors with low level copy loss of LIG1 (GISTIC = −1, likely single copy number loss) display significantly higher chromosomal instability and multi-gene proliferation scores and significantly lower Signature 3 (COSMIC mutational signature associated with homologous recombination defect) than tumors that that are WT for or show gain of CNA (GISTIC >= 0). T-tests and wilcoxon rank sum tests were used to compare LIG1 loss cases to LIG1 intact (WT/Gain) cases.