Table 1.
Brominated (BFRs) | Organophosphates (OPFRs) | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TBBPA | BDE-47 | BDE-99 | TPHP | TBOEP | IDDPHP | IPPHP | TCP | THCIPP | t-BPDPHP | TOCP | EHDPHP | BBOEP | TCEP | TCIPP | ||
Proliferation by area | BMC20 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Proliferation by BrdU | - | - | - | - | - | - | - | 0.86 | - | - | 17.2 | 0.02 | - | 18.9 | - | |
Proliferation CTB | - | - | - | - | - | - | 9.62* | - | 19.2 | - | - | - | 19.9 | - | - | |
Proliferation LDH | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
Radial glia migr. 72 h | BMC20 | 1.93 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Radial glia migr. 120 h | 2.15 | - | - | - | - | - | - | - | - | 15.73 | - | - | - | - | - | |
Neuronal migration | 2.60 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
Oligo. migration | 2.23 | - | - | - | - | - | - | - | - | 12.54 | 8.12 | - | - | - | - | |
LDH 72 h | 1.75 * | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
LDH 120 h | 0.63 * | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
CTB 120 h | 1.38 | - | 3.56* | - | - | 1.79* | 5.50* | - | 11.2 | - | 12.9* | 5.88* | - | - | - | |
Neurite length | 2.31 | - | - | - | - | - | - | - | - | 9.55 | 0.12 | 17.9 | - | - | - | |
Neurite area | 2.49 | - | - | - | - | - | - | - | - | 15.8 | 0.51 | 19.8 | - | - | - | |
Number of nuclei | 1.49 | - | - | - | - | 3.10 * | - | - | - | 19.8 | - | 8.72 * | - | - | - | |
Number of neurons | 2.18 | - | - | - | - | - | - | - | 12.8 * | - | 18.8 | 10.3 | - | - | - | |
Number of oligodendrocytes | BMC50 | - | 0.03 * | - | - | - | - | - | - | - | - | - | - | - | - | - |
0.55 | 8.00 | 1.91 | 6.39 | 7.62 | 6.45 | 6.88 | 13.2 | 3.13 | 3.37 | 4.49 | 13.1 | - | - | - | ||
NCC migration | BMC25 | 1.56 | 2.71 | 15.8 | 10.0 | - | 14.1 | 6.66 | 7.99 | - | 4.05 | 3.32 | 6.46 | - | - | - |
NCC viability | BMC10 | 2.78 | 14.2 | - | - | - | - | - | 16.9 | - | 14.0 | 3.44 | 11.4 | - | - | - |
LUHMES neurite area | BMC25 | - | - | 12.3 | - | - | - | - | - | - | - | - | - | - | - | - |
LUHMES viability | - | 13.5 | 15.0 | - | - | - | - | - | - | - | - | - | - | - | - | |
Sensory N. neurite area | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
Sensory N. viability | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Induced effects. Numbers are given in μM. No value assumes BMCs > 20 μM