. Author manuscript; available in PMC: 2022 Oct 2.

Published in final edited form as: Cell Biol Toxicol. 2021 May 10;38(5):781–807. doi: 10.1007/s10565-021-09603-2

Table 1.

Summary of BMCs across the DNT in vitro testing battery. Specific hits are highlighted bold and borderline hits are marked cursive. Red colored specifies most sensitive endpoints (MSEs).

		Brominated (BFRs)			Organophosphates (OPFRs)
		TBBPA	BDE-47	BDE-99	TPHP	TBOEP	IDDPHP	IPPHP	TCP	THCIPP	t-BPDPHP	TOCP	EHDPHP	BBOEP	TCEP	TCIPP
Proliferation by area	BMC₂₀	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Proliferation by BrdU		-	-	-	-	-	-	-	0.86	-	-	17.2	0.02	-	18.9	-
Proliferation CTB		-	-	-	-	-	-	9.62^*	-	19.2	-	-	-	19.9	-	-
Proliferation LDH		-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Radial glia migr. 72 h	BMC₂₀	1.93	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Radial glia migr. 120 h		2.15	-	-	-	-	-	-	-	-	15.73	-	-	-	-	-
Neuronal migration		2.60	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Oligo. migration		2.23	-	-	-	-	-	-	-	-	12.54	8.12	-	-	-	-
LDH 72 h		1.75 ^*	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LDH 120 h		0.63 ^*	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CTB 120 h		1.38	-	3.56^*	-	-	1.79^*	5.50^*	-	11.2	-	12.9^*	5.88^*	-	-	-
Neurite length		2.31	-	-	-	-	-	-	-	-	9.55	0.12	17.9	-	-	-
Neurite area		2.49	-	-	-	-	-	-	-	-	15.8	0.51	19.8	-	-	-
Number of nuclei		1.49	-	-	-	-	3.10 ^*	-	-	-	19.8	-	8.72 ^*	-	-	-
Number of neurons		2.18	-	-	-	-	-	-	-	12.8 ^*	-	18.8	10.3	-	-	-
Number of oligodendrocytes	BMC₅₀	-	0.03 ^*	-	-	-	-	-	-	-	-	-	-	-	-	-
Number of oligodendrocytes	BMC₅₀	0.55	8.00	1.91	6.39	7.62	6.45	6.88	13.2	3.13	3.37	4.49	13.1	-	-	-
NCC migration	BMC₂₅	1.56	2.71	15.8	10.0	-	14.1	6.66	7.99	-	4.05	3.32	6.46	-	-	-
NCC viability	BMC₁₀	2.78	14.2	-	-	-	-	-	16.9	-	14.0	3.44	11.4	-	-	-
LUHMES neurite area	BMC₂₅	-	-	12.3	-	-	-	-	-	-	-	-	-	-	-	-
LUHMES viability		-	13.5	15.0	-	-	-	-	-	-	-	-	-	-	-	-
Sensory N. neurite area		-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
Sensory N. viability		-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

Induced effects. Numbers are given in μM. No value assumes BMCs > 20 μM