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. Author manuscript; available in PMC: 2022 Dec 28.
Published in final edited form as: Cancer Res. 2022 Nov 15;82(22):4261–4273. doi: 10.1158/0008-5472.CAN-21-3214

Figure 6. WNT signaling components are expressed at higher levels in BC lung tumors without Rbms3.

Figure 6.

A&B: Representative images of β-catenin expression as assessed by indirect immunofluorescent in tumor bearing FFPE BC mouse lung sections (shown at 2x, 5x, and 40 magnifications) initiated with either A: sgNT-CRE or B: sgRbms3-CRE. Scale bars are shown in white in the bottom left corner of each image as indicated. C: Median fluorescence intensity quantitation using cellprofiler software. D: qRT-PCR analysis of BC organoids from the indicated viral initiation groups using probes to detect Ctnnb1, Ccnd1, Axin2, Lgr5, or c-Myc mRNAs. Mean is graphed with error bars as SEM. Statistical analysis was conducted using a paired T test; * = p < 0.05; **= p < 0.01; ***= p <0.001; **** = p < 0.0001.