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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Neuropsychopharmacology. 2010 Mar 31;35(8):1775–1787. doi: 10.1038/npp.2010.44

Figure 5.

Figure 5

Subchronic THC reduces CB1 receptor-mediated G-protein activity in both FAAH+/+ and FAAH−/− mice, but subchronic AEA does not significantly alter CB1 receptor-mediated activity. Densitometric analysis of net WIN55,212-2-stimulated [35S]GTPγS binding in FAAH+/+ and FAAH−/− mice treated with vehicle (VEH), THC, or anandamide (AEA) in CB1 receptor-containing brain regions: caudate putamen (CPu), hippocampus (Hip) and cerebellum (Cblm). No significant genotype differences were observed regardless of treatment or brain region. Values represent mean net [35S]GTPγS binding (nCi/g) ± SEM, n= 4-6 mice/group.