Figure 3.

Organs potentially involved in patients with HE and HE-related organ damage (HES)

Compilation of disorders that are accompanied by eosinophilia and affect distinct organ systems. Organ involvement depends on the underlying etiology (disease), the exogenous (infectious), molecular and immunological triggers, and the number and degree of activation of infiltrating eosinophils. In patients with HES, multiple organs may be involved, and the same holds true for patients with defined syndromes, such as Gleich’s syndrome or patients with eGPA. However, there are also patients with HES or other conditions accompanied by HE where only a single organ system is involved. Examples are eosinophilic colitis, eosinophilic gastritis or eosinophilic pneumonia. In cases with primary (neoplastic) HES, the cardiovascular system is often affected, but cardiovascular complications may develop in any form of HES. Abbreviations: eGPA, eosinophilic granulomatosis with polyangiitis.