Table 1:

Characteristics of patients with vs. without metastases (n=251)

Variables	Metastases (n=38)	No Metastases (n=213)	p-value
Age, median (IQR)	59 (56-63)	59 (54-65)	0.654
PSA, median (IQR)	7.0 (5.3-8.7)	5.5 (4.4-8.4)	0.035
Race, n (%)
White	32 (16.0)	168 (84.0)	0.196
Black	6 (18.8)	26 (81.3)
Other	0 (0)	16 (100.0)
Prostatectomy year, median (IQR)	2008 (2007-2009)	2009 (2008-2011)	0.006
Prostatectomy Gleason score, n (%)			<0.0001
3+4	1 ( 0.7)	135 (99.3)
4+3	9 (16.1)	47 (83.9)
8	6 (26.1)	17 (73.9)
9-10	22 (66.7)	11 (33.3)
Pathology stage, n (%)			<0.0001
Organ confined	6 (4.6)	124 (95.4)
Extraprostatic extension	10 (12.5)	70 (87.5)
Seminal vesicle involvement	10 (43.5)	13 (56.5)
Lymph node involvement	12 (85.7)	2 (14.3)
Surgical margins, n (%)			0.003
Negative	23 (11.7)	174 (88.3)
positive	14 (28.6)	35 (71.4)
NCCN Risk, n (%)			0.0002
Intermediate	17 ( 9.1)	169 (90.0)
High	15 (29.4)	36 (70.6)
Salvage treatment, n (%)			<0.0001
None	21 (10.9)	171 (89.1)
ADT only	4 (66.7)	2 (33.3)
Radiation only	8 (32.0)	17 (68.0)
ADT+Radiation	5 (35.7)	9 (64.3)
CAPRA-S, median (IQR)	7 (4-8)	2 (1-4)	<0.0001
Cores with PACCs, median (IQR)	1 (0-2)	0 (0-1)	0.017
Cores with PACCs, n (%)*			0.029
0	18 (11.8)	134 (88.2)
≥1	20 (22.5)	69 (77.5)
Total number of PACCs, median (IQR)	1 (0-3)	0 (0-1)	0.011
Total number of PACCs, n (%)*			0.029
0	18 (11.8)	134 (88.2)
≥1	20 (22.5)	69 (77.5)

Abbreviations: IQR, interquartile range; NCCN, National Comprehensive Cancer Network; ADT, androgen deprivation therapy; PACCs, polyaneuploid cancer cells

^*Binary classification of total PACCs and cores with PACCs gives the same distribution