A) Schematic of drug-loaded hydrogel assembly by guest-host interaction. B) Oscillatory time sweeps of individual components (20%w/v CDNP, green and 7.5%w/v Ad-HA, blue) and formed polymer-CDNP hydrogel (1:1.5 ratio of 7.5%w/v Ad-HA: 20%w/v CDNP, purple); storage (G’, circles), and loss (G”, squares) moduli at 1.0 Hz, 1.0% strain. C) Storage and loss moduli of hydrogels formed from 82 kDa Ad-HA (Low, left), 337 kDa Ad-HA (Low, middle), and 82 kDa Ad-HA (High, right) at varying volumetric ratios of Ad-HA:CDNP. Time sweeps were performed at 10.0 Hz, 1.0% strain; mean ± SD, n = 2.