TABLE 1.
Baseline characteristics of the covariates considered for the analysis for decision-making that either followed the pathway (FFT-clinical algorithm) or not (nonpathway)
| Total Continuous variables | Non-pathway (treatment off FFT algorithm) 835 |
Pathway (treatment per FFT algorithm) 948 |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | Med | Min | Max | SD | N | Mean | Med | Min | Max | SD | N | P | |
|
| |||||||||||||
| BMI | 31.65 30.5 | 18.7 | 66.8 | 8.03 | 743 | 34.17 | 32 | 18.8 | 69.3 | 9.25 | 946 | <0.01 | |
| CCI | 2.43 2 | 0 | 14 | 2.34 | 835 | 2.12 | 2 | 0 | 14 | 2.07 | 948 | 0.02 | |
| Age (years) | 59.07 60 | 17 | 121 | 18.41 | 835 | 59.22 | 60 | 13 | 106 | 16.97 | 948 | 0.93 | |
| Admission ALT | 37.2 | 27 | 1 | 344 | 36.82 | 815 | 45.91 | 32 | 1 | 1068 | 59.48 | 943 | <0.01 |
| Admission ANC | 5.49 4.8 | 0.8 | 48.89 | 3.52 | 809 | 5.25 | 4.7 | 0.3 | 22.63 | 2.77 | 933 | 0.52 | |
| Admission AST | 45.53 | 34 | 8 | 452 | 43.64 | 815 | 53.42 | 38 | 7 | 1172 | 69.17 | 943 | <0.01 |
| Admission BNP | 254.9 | 35.5 | 1 | 10580 | 901.58 | 210 | 84 | 18 | 1 | 2036 | 198 | 288 | <0.01 |
| Admission BUN | 19.13 14 | 3 | 129 | 15.21 | 828 | 17.44 | 14 | 2 | 136 | 13.08 | 947 | 0.03 | |
| Admission CK | 312.28 | 130 | 6 | 6945 | 652.8 | 318 | 318.42 | 130 | 13 | 5924 | 589.13 | 632 | 0.40 |
| GFR | 73.86 75.95 | 4.11 | 138.67 | 29.64 | 835 | 75.17 | 78.53 | 6.43 | 140.69 | 28.07 | 948 | 0.34 | |
| Admission LDH | 355.49 | 322 | 101 | 2365 | 181.65 | 513 | 380.01 | 352 | 102 | 6577 | 287.84 | 633 | <0.01 |
| Admission Albumin | 3.48 3.5 | 1.2 | 4.9 | 0.53 | 815 | 3.44 | 3.5 | 1.3 | 5 | 0.47 | 943 | 0.05 | |
| Admission Calcium | 8.88 8.8 | 6.1 | 11.6 | 0.64 | 828 | 8.75 | 8.7 | 6.2 | 12.4 | 0.55 | 947 | <0.01 | |
| ddimer | 1.76 0.83 | 0.01 | 35.59 | 3.86 | 567 | 1.22 | 0.71 | 0.02 | 23.17 | 1.86 | 700 | <0.01 | |
| Admission Platelet | 231.61 | 212 | 55 | 800 | 97.39 | 834 | 221.53 | 207 | 42 | 759 | 84.55 | 948 | 0.05 |
| Categorical variables | Number yes | % | Number yes | % | |||||||||
| Cultures_Positive | 31 | 3.71 | 20 | 2.11 | 0.0466 | ||||||||
| ID_CONSULT | 3 | 0.36 | 5 | 0.53 | 0.7303 | ||||||||
| Immunocompromised | 37 | 4.43 | 28 | 2.95 | 0.1012 | ||||||||
| Pregnant | 36 | 4.31 | 10 | 1.05 | <0.01 | ||||||||
| Sepsis | 40 | 4.79 | 21 | 2.22 | <0.01 | ||||||||
| Race | <0.01 | ||||||||||||
| White-NH | 239 | 28.62 | 171 | 18.04 | |||||||||
| White-Hisp | 76 | 9.10 | 117 | 12.34 | |||||||||
| Other | 230 | 27.54 | 329 | 34.70 | |||||||||
| Black | 290 | 34.73 | 331 | 34.92 | |||||||||
| Sex | 0.9621 | ||||||||||||
| Female | 429 | 51.38 | 489 | 51.58 | |||||||||
| Male | 406 | 48.62 | 459 | 48.42 | |||||||||
| Treatment | Number yes | % | Number yes | % | |||||||||
| Oxygen_Orders | 543 | 65.03 | 788 | 83.12 | <0.01 | ||||||||
| Supplemental_O2 | 604 | 72.34 | 732 | 77.22 | 0.0186 | ||||||||
| Antibiotics | 448 | 53.65 | 327 | 34.49 | <0.01 | ||||||||
| Antivirals | 379 | 45.39 | 468 | 49.37 | 0.0964 | ||||||||
| Remdesivir | 359 | 42.99 | 462 | 48.73 | 0.0173 | ||||||||
| Steroids | 498 | 59.64 | 594 | 62.66 | 0.2054 | ||||||||
Note: See Figure 2 for details of treatment with anticoagulants.
Abbreviations: ALT, alanine transaminase; ANC, absolute neutrophil count; AST, aspartate aminotransferase; BMI, body mass index; BNP, B-type natriuretic peptide; BUN, blood urea nitrogen; CCI, charlson comorbidity index; CK, creatine kinase; GFR, glomerular filtration rate; LDH, lactate dehydrogenase.