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. Author manuscript; available in PMC: 2022 Dec 16.
Published in final edited form as: Cell Mol Life Sci. 2022 Jun 15;79(7):363. doi: 10.1007/s00018-022-04396-x

Figure 5. TETs regulate gene expression by both enzyme-dependent and -independent mechanisms.

Figure 5.

After binding to DNA regulator regions, TETs regulate target gene expression by 1) enzymatic demethylation of 5mC; and 2) recruiting histone modifiers, including OGT, Sin3A/HDACs, or HATs.