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. Author manuscript; available in PMC: 2023 Jan 14.
Published in final edited form as: J Am Chem Soc. 2022 Dec 21;145(1):537–550. doi: 10.1021/jacs.2c10775

Figure 4. Activity and selectivity of CYP119 based biocatalysts for α-C─H functionalization of N-aryl-pyrrolidines with diazoacetone.

Figure 4.

Yields, TON, and enantioselectivity as determined from whole cell reactions under standard reaction conditions with diazoacetone, as described in Table 1. The lines indicate the relationship among the enzyme variants along the evolutionary lineage.