Table 1.
Baseline characteristics (non italic) and change in secondary periodontitis outcome parameters from baseline to month 3 (in italics), stratified by DAS28ESR improvement of at least 0.6 points upon periodontitis therapy at month 3. Statistics for binary variables were Fisher’s exact text and for quantitative data Wilcoxon’s rank sum test.
| Parameter | Unit | Non-responder (n=3) | Responder (n=5) |
|---|---|---|---|
| Age | [years] | 62±13 | 61±10 |
| Female | n= | 3 | 3 |
| Body mass index | [kg/m2] | 27±7 | 29±5 |
| Disease duration | [years] | 18±10 | 10±6 |
| Previous csDMARDs | n, median | 2 | 2 |
| Previous bDMARDs | n, median | 6 | 5.5 |
| DAS28ESR* | Mean ± SD | 5.7±0.4 | 4.8±0.3 |
| Total number of teeth | Median [IQR] | 20 [8; 21] | 14 [8; 16] |
| Number of pockets > 4mm | Median [IQR] | 15 [7; 17] | 14 [8; 15] |
| Probing depth | mm, median [IQR] | 3.1 [2.6; 3.4] | 3.9 [3.8; 3.9] |
| Change in probing depth | mm, median [IQR] | 1.0 (0.9–1.1) * | 1.4 [1.2–1.5], n=4 |
| Clinical Attachment level (CAL)** | mm, median [IQR] | −3.5 [−5; −2.2] | −6.9 [−7; −6.6] |
| Change in CAL | mm, median [IQR] | 0.2 [0–1.1] * | 1.2 [0.9–1.4], n=4 |
| Bleeding on probing (BOP) | Sites in %, median [IQR] | 27 [18; 83] | 40 [35; 46] |
| Change in BOP | Sites in %, median [IQR] | −19 [−48, −7] | −32 [−40, −20], n=4 |
| O’Leary plaque index | Median [IQR] | 34 [16; 52] | 80 [0; 91] |
| A. actinomycetemcomitans | N | 0 | 0 |
| Porphyromonas gingivalis | N | 1 | 1 |
| Prevotella intermedia | N | 0 | 1 |
| Capnocytophaga sp.# | N | 1 | 4 |
| Rheumatoid factor | IU/ml | 420 [63; 777] | 157 [137; 561] |
| CCP antibodies | IU/ml | 169 [155; 183] | 190 [188; 191] |
| rVim | OD, median [IQR] | 0 [0; 0.008] | 0 [0; 0] |
| cVim | OD, median [IQR] | 0.026[0.01; 1.344] | 0.078 [0.043; 0.098] |
| rFib | OD, median [IQR] | 0 [0; 0.038] | 0 [0; 0] |
| cFib | OD, median [IQR] | 0.286 [0.001; 0.694] | 0.158 [0.109; 0.674] |
| REP-1 | OD, median [IQR] | 0.008 [0.003; 0.012] | 0.004 [0.001; 0.006] |
| CEP-1 | OD, median [IQR] | 0.026 [0.01; 0.349] | 0.013 [0.013; 0.452] |
| rTNC5 | OD, median [IQR] | 0.061 [0.037; 0.063] | 0.038 [0.029; 0.041] |
| cTNC5** | OD, median [IQR] | 0.085 [0.074; 0.215] | 0.051 [0.037; 0.054] |
*
p=0.03,
**
p=0.05,
#
p=0.014.
Abbreviations: IQR: interquartile range, IU: international unit, SD: standard deviation. rVim: antibodies against arginine baring, cVim, antibodies against citrullinated vimentin peptides. rFib and cFib = antibodies against fibrinogen, REP-1 and CEP-1 = antibodies against enolase and rTNC5 and cTNC5 against tenascin-C.