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. Author manuscript; available in PMC: 2023 Apr 19.
Published in final edited form as: Hypertension. 2023 Feb 20;80(5):981–994. doi: 10.1161/HYPERTENSIONAHA.122.20760

Figure 1. Effects of 8-aminoguanine on renal excretory function and renal cortical and medullary microdialysate levels of inosine.

Figure 1.

Timed collections of urine from the ureter and renal cortical and medullary microdialysates were obtained from anesthetized rats from 0-30 min (Period 1), 40-70 min (Period 2) and 85-115 min (Period 3) into the protocol. Rats received an IV injection of 8-aminoguanine (33.5 μmoles/kg) immediately after Period 1. Urine volumes (A), excretion rates of sodium (B), glucose (C) and potassium (D) and cortical (E) and medullary (F) concentrations of inosine were determined. Values are means and SEMs for the indicated sample size (n). ANOVA, analysis of variance; *P<0.05 vs Period 1.