Skip to main content
. Author manuscript; available in PMC: 2023 Apr 19.
Published in final edited form as: Hypertension. 2023 Feb 20;80(5):981–994. doi: 10.1161/HYPERTENSIONAHA.122.20760

Figure 4. Effects of 8-aminoguanine on medullary blood flow (MBF) in rats pretreated with an A2A receptor antagonist, an A2B receptor antagonist or both an A2A and A2B receptor antagonist.

Figure 4.

Anesthetized rats were pretreated intravenously with either vehicle [A; Control Group], 10 mg/kg of ZM 241385 (B; A2A Antagonist Group), 30 mg/kg of PSB 1115 (C; A2B Antagonist Group) or ZM 241385 plus PSB 1115 (D; A2A + A2B Antagonist Group), and 15 min later MBF was averaged over 30 min (Basal). Next, rats received an IV injection of 8-aminoguanine (33.5 μmoles/kg), and after approximately 1 hr MBF was averaged over 30 min (8-Aminoguanine). P-values are from paired t-tests. Values are means and SEMs for the indicated sample size (n).