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. Author manuscript; available in PMC: 2023 Apr 19.
Published in final edited form as: Hypertension. 2023 Feb 20;80(5):981–994. doi: 10.1161/HYPERTENSIONAHA.122.20760

Figure 5. Effects of BAY 60-6583 on renal excretory function.

Figure 5.

BAY 60-6583 was infused directly into the renal artery of anesthetized rats at increasing doses [0 (vehicle; basal), 1 and 3 nmol/kg/min]. Each dose of Bay 60-6538 was administered for 40 min and timed collections of urine were obtained from the ureter between 10 and 40 min after initiating a given dose of BAY 60-6538, and urine volumes (A) and excretion rates of sodium (B) and potassium (C) were determined. Also shown are medullary blood flows during the infusions (D). Values are means and SEMs for the indicated sample size (n). ANOVA, analysis of variance; *indicates P<0.05 vs 0 (vehicle; basal).