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Centi-C10 antibody properties and discovery process. a) Centi-C10 potency quantified by neutralization assays of spike-pseudotyped lentivirus (mean ± SD, assayed in duplicate). b) Antibodies capable of binding the SARS-CoV-2 receptor binding domain (RBD), and thus blocking the binding of the virus to ACE-2 receptors on human cells, were discovered by multiple rounds of panning and selection from an ScFV phage library built from a SARS-CoV-1-binding parental antibody.
