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. Author manuscript; available in PMC: 2023 Apr 5.
Published in final edited form as: Muscle Nerve. 2022 Oct 3;67(2):101–110. doi: 10.1002/mus.27721

TABLE 2.

Type of peripheral neuropathy associated with DNA repair disorders

DNA repair disorder Sensory vs motor neuropathy Axonal vs demyelinating neuropathy Age of neuropathy onset
Xeroderma pigmentosum Sensorimotor (XPA), sensory (XPD) Axonal Detected as early as 3 years for XPA, detected as early as adolescence for XPD46
Trichothiodystrophy Motor Demyelinating Detected as early as 6 months of age56
Cockayne syndrome Sensorimotor Demyelinating Severe slowing of conduction velocities observed at 2 years of age71
Werner syndrome Sensorimotor Axonal and demyelinating Neuropathy has been detected in the fourth decade of life and later, onset unclear80–82
Ataxia telangiectasia Sensorimotor Axonal Childhood onset with progression over time131

Abbreviation: XP, xeroderma pigmentosum.