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. Author manuscript; available in PMC: 2023 Jul 4.
Published in final edited form as: Pediatr Crit Care Med. 2023 Apr 24;24(7):563–573. doi: 10.1097/PCC.0000000000003244

Figure 2:

Figure 2:

Classification and regression tree (CART)-based PERSEVERE-II model stratifying septic children into one of seven terminal nodes (TN). All subjects start at the root node at the top, and subsequently stratified according to biomarker levels into TNs. TNs 1, 2, and 5 (green) are low-risk of 28-day mortality. TNs 4 and 6 (blue) are medium-risk. TNs 3 and 7 (red) are high-risk). For comparison, the color-coded low-, medium-, and high-risk TNs are identical to those identified using the PERSEVERE-II model in children from the United States, albeit with lower mortality rates in the original cohort (low-risk < 2%, medium-risk 15-20%, high-risk > 40% predicted mortality risk). TN7 in this cohort from Aga Khan University Hospital is pruned from the original PERSEVERE-II due to only having two subjects.