Table 1.

Immune composition of normal brain and EGFR glioblastomas.

	Percent of CD45+ cells ± SEM			P values
	Normal Brain	EGFR WT	EGFR vIII	WT vs Normal	vIII vs Normal	WT vs vIII
CD8+ T cells	4.12 ± 1.35	27.03 ± 3.68	27.29 ± 1.5	0.0025	<0.0001	n.s.
CD4+ T cells	1.12 ± 0.59	7.63 ± 1.5	2.21 ± 0.43	0.0214	n.s.	0.0042
Regulatory T cells	n.d.	4.78 ± 1.69	0.00021 ± 0.0001	n.d.	n.d.	0.0159
PMN-MDSCs	0.33 ± 0.15	5.46 ± 1.01	14.33 ± 1.51	0.0088	<0.0001	0.0001
M-MDSCs	4.91 ± 2.44	17.02 ± 2.72	16.46 ± 3.04	0.0228	0.0387	n.s.
BMDMs	4.79 ± 2.44	28.3 ± 4.14	24.3 ± 2.69	0.005	0.001	n.s.
Microglia	84.72 ± 5.03	9.76 ± 2.33	15.41 ± 1.03	<0.0001	<0.0001	0.0477

Flow cytometry analysis of intratumoral CD45+ cells for the indicated cell type (percent). Data is Mean±SEM of biological replicates, p values from unpaired t test, two-tailed. ns, not significant.