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. Author manuscript; available in PMC: 2023 Jun 9.
Published in final edited form as: Eur Respir J. 2023 Jun 8;61(6):2201799. doi: 10.1183/13993003.01799-2022

Figure 8. Berbamine ameliorates pulmonary fibrosis in mouse models.

Figure 8

a, UMAP and differential gene expression between EC-like myofibroblasts and ECs.

b, Gene expression in tdTomato+VE-cadherin+ cells isolated from the lungs of SM22acreRosatdTomato mice and treated with berbamine (20 μM) with transfection of MGP siRNA or SCR (n=6). Fn1, fibronectin 1.

c, MT staining of pulmonary tissues from VE-cadherincreMgpflox/flox and Sm22acreMgpflox/flox mice after berbamine treatment (100 ng/g, daily) (n=12).

d, Quantification of MT staining and expression of Col3a1 and Fn1 in pulmonary tissues from VE-cadherincreMgpflox/flox and Sm22acreMgpflox/flox mice after berbamine treatment (n=9 for quantification of MT and n=6 for gene expression).

b and d were analyzed for statistical significance by ANOVA with post hoc Tukey’s test. The bounds of the boxes are upper and lower quartiles with data points. The line in the box is median. Error bars are maximal and minimal values. ***, P<0.0001.