Table 1.

Immunization of BALB/c mice with the DNA vaccine encoding Hsd17b12^114T epitope administered in the protecting setting inhibits growth of Meth A

DNA vaccine	MTD ± MSEa	P value
pCI	9.2 ± 0.9
IL-12	9.0 ± 0.4	NS
Hsd17b12114T	3.6 ± 1.2	<0.05
Hsd17b12114T + IL-12	4.5 ± 1.5	<0.05

Non-viral plasmid DNA vaccines expressing the Hsd17b12^114T and/or IL-12 were used for gene gun immunization of groups of three BALB/c mice each. The mice were immunized twice with a 10–14 day interval with the indicated DNA vaccines prior to being challenged with 2.5 × 10⁵ Meth A sarcoma. No enhancement of inhibition evident when co-administered with a IL-12 DNA vaccine

NS indicates non-significance

^aTumor measurements taken on day 21 post-challenge