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. Author manuscript; available in PMC: 2010 Sep 3.
Published in final edited form as: J Neurosci. 2010 Mar 3;30(9):3239–3253. doi: 10.1523/JNEUROSCI.4775-09.2010

Figure 6.

Figure 6

Impaired light adaptation of ERG b-waves in Pd−/− mice probed with saturating flashes.

(A) Representative ERG responses in WT and Pd−/− mice evoked by a flash of 1 cd·s/m2 photoacivating ~200 rhodopsin molecules per rod. Up to 10 trials with inter-trial times of 15 s were averaged for each condition. Recordings were performed in the dark and after 2 min adaptation to background light of several luminances indicated to the left of the traces. The amplitudes of b-waves (B) and a-waves (C) were normalized to dark-adapted values (R/Rmax) and plotted as functions of background luminance. Closed symbols represent the data obtained from WT and Pd−/− mouse lines used in the rest of this study. The data are fitted using Equation 2 and plotted as solid lines. Open symbols represent the data obtained from WT (Pd+/+) and Pd−/− littermates. The parameters of all fits and the number of analyzed animals of each type are summarized in Table 4.