(A) Schematic of the experimental procedure. Mice were fed an FRD or ND for 4 or 12 weeks before EAE was induced and (B) disease severity monitored via scoring, survival, and area under the curve. N= 5 mice per group, Mantel-Cox log-rank test for survival. Mice were fed a fructose rich diet, ND, or fructose-supplemented water (30% w:v fructose) for 6 weeks before EAE was induced and (C) disease severity monitored via scoring, survival, and area under the curve. N=10 mice per group, 2-way ANOVA for EAE, Mantel-Cox log-rank test for survival.