. Author manuscript; available in PMC: 2010 May 21.

Published in final edited form as: Hum Genomics. 2009 Oct;4(1):2–20. doi: 10.1186/1479-7364-4-1-2

Table 2.

Accuracy of the association parameter as ln odds of being affected given two copies of the disease allele versus one copy for a sample size of 1,000 individuals

Model^*		Nuclear		Extended
Model^*		RAND	ASC	RAND	ASC
FP–FP	Est	2.529	2.479	2.511	2.561
	rMSE	0.1709	0.1210	0.1530	0.2030
FP–P	Est	2.537	2.509	2.517	2.524
	rMSE	0.1789	0.1510	0.1591	0.1661
P–FP	Est	2.780	2.655	2.763	2.722
	rMSE	0.1775	0.0529	0.1603	0.1196
P–P	Est	2.780	2.648	2.768	2.724
	rMSE	0.1775	0.0458	0.1655	0.1212

Model indicates the variance components that were simulated followed by those included in the analysis model (F = familial and P = polygenic); Est is the average estimate across all replicates of that model; rMSE is the square root of the mean square error; ASC represents the analysis of an ascertained sample using ascertainment correction and RAND represents the analysis of a random sample without any such correction.