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. Author manuscript; available in PMC: 2010 May 21.
Published in final edited form as: Hum Genomics. 2009 Oct;4(1):2–20. doi: 10.1186/1479-7364-4-1-2

Table 4.

Accuracy of variance components as proportions of the total variance, N=1,000

Parameter Model Nuclear Extended
RAND ASC RAND ASC
Marital MP–MP Est 0.079 0068 0.0775 0.0696
rMSE 0.0877 0.0990 0.0894 0.0693
SMP–SMP Est 0.1743 0.0636 0.1291 0.0555
rMSE 0.0316 0.0781 0.0141 0.0866
Sibling SP-SP Est 0.0574 0.0669 0.0549 0.0713
rMSE 0.1095 0.1000 0.1122 0.0959
SMP–SMP Est 0.0549 0.0554 0.057 0.0579
rMSE 0.0883 0.1118 0.0860 0.1090
Polygenic FP–FP Est 0.0896 0.0604 0.1711 0.1388
rMSE 0.0775 0.1068 0.0000 0.0283
MP–MP Est 0.0741 0.0655 0.0775 0.0643
rMSE 0.0927 0.1015 0.0894 0.1030
P–P Est 0.063 0.0805 0.0602 0.0755
rMSE 0.1039 0.1196 0.1068 0.1249
SMP–SMP Est 0.2169 0.0617 0.1759 0.0559
rMSE 0.0742 0.0800 0.0332 0.0860
SP–SP Est 0.0962 0.0723 0.0782 0.0603
rMSE 0.0707 0.0949 0.0889 0.1068
Familial FP–FP Est 0.1133 0.0122 0.033 0.0139
rMSE 0.0539 0.3521 0.1342 0.1530
P-FP Est 0.0198 0.0032 0.048 0.0102
rMSE 0.0200 0.0032 0.0480 0.0100
*

Model indicates the variance components that were simulated followed by those included in the analysis model (F = familial, M = marital, S = sibling and P = polygenic); Est is the average estimate across all replicates of that model; rMSE is the square root of the mean square error; ASC represents the analysis of an ascertained sample using ascertainment correction and RAND represents the analysis of a random sample without any such correction.