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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: ACS Med Chem Lett. 2010;1(3):110–114. doi: 10.1021/ml100020e

Table 1.

Inhibitory Activities of Compounds 1 – 4 against Plk1 PBD

Compound PBD inhibitory activitya Kd (μM)
1 High 0.445
2 Moderate 2.7 (estimated)
3 No activity -
4 Not determined -
a

Measured by an ELISA-based Plk1 PBD competition assay.