Table 2.
Odds ratios from fully adjusted and partially adjusted multiple logistic regression models
| Minimally adjusted model (individual risk factors) |
Fully adjusted model (all risk factors) |
|||||
|---|---|---|---|---|---|---|
| Odds ratio | 95% Confidence interval | P-value | Odds ratio | 95% Confidence interval | P-value | |
| Age | — | — | — | 1.02 | (1.02, 1.02) | 1.60e-160 |
| Male sex | — | — | — | 0.74 | (0.73, 0.76) | 4.20e-144 |
| Chol med | — | — | — | 1.51 | (1.46, 1.56) | 7.18e-142 |
| PRSCAD | 1.33 | (1.30, 1.36) | 5.48e-116 | 1.30 | (1.27, 1.33) | 8.98e- 98 |
| HeFH status | 1.33 | (1.13, 1.57) | 5.64e-4 | 1.31 | (1.11, 1.54) | 1.25e-3 |
| Lp(a) | 1.20 | (1.17, 1.23) | 2.49e- 48 | 1.17 | (1.14, 1.20) | 1.44e- 36 |
| Hypertension | 1.18 | (1.15, 1.20) | 9.80e-45 | 1.18 | (1.15. 1.21) | 2.09e- 43 |
| ApoB:ApoAI | 1.17 | (1.15, 1.20) | 3.14e- 36 | 1.13 | (1.10, 1.16) | 9.70e- 20 |
| Triglycerides | 1.11 | (1.08, 1.13) | 2.63e-15 | 1.07 | (1.04, 1.10) | 1.33e-6 |
| hsCRP | 1.02 | (1.00, 1.05) | 0.05 | 0.995 | (0.97, 1.02) | 0.67 |
| WHR | 0.99 | (0.96, 1.02) | 0.55 | 0.961 | (0.93, 0.99) | 6.75e-3 |
| Ever smoked | 0.96 | (0.95, 0.99) | 2.20e-3 | 0.967 | (0.95, 0.99) | 1.08e-3 |
| Diabetes mellitus | 0.92 | (0.88, 0.96) | 8.41e- 5 | 0.889 | (0.85, 0.93) | 1.24e-7 |
The table above presents multiple logistic regression modeling of self-reported FHHD, where continuous variables were divided into quintiles. The 2nd–5th quintiles were compared to the 1st quintile, serving as the reference. In the minimally adjusted model, individual risk factors are modeled as predictors of reported FHHD, controlling for age, sex, and cholesterol-lowering medication use. In the fully adjusted model, analysis is adjusted for all other variables in the model.
ApoB:ApoAI, apolipoprotein B-to-apolipoprotein AI ratio [2nd–5th quintiles vs. 1st quintile (reference)]; Chol Med, cholesterol-lowering medication use; PRSCAD, polygenic risk score for coronary artery disease [2nd–5th quintiles vs. 1st quintile (reference)]; HeFH, heterozygous familial hypercholesteremia; hsCRP, high sensitivity C-reactive protein mg/L [2nd–5th quintiles vs. 1st quintile (reference)]; Lp(a), Lipoprotein(a) nmol/L [2nd–5th quintiles vs. 1st quintile (reference)]; triglycerides, triglycerides mmol/L [2nd–5th quintiles vs. 1st quintile (reference)]; WHR, waist to hip ratio [2nd–5th quintiles vs. 1st quintile (reference)].