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. Author manuscript; available in PMC: 2010 Apr 30.
Published in final edited form as: Eur J Neurosci. 2010 Mar;31(5):827–835. doi: 10.1111/j.1460-9568.2010.07107.x

Fig. 2.

Fig. 2

XE991 increases fast firing in DA neurons in vitro. (A) Intracellular recording showing that a given amount of current (+ 120 pA) elicits more spikes (truncated in the figure) in the presence of XE991. The experiment was performed in the presence of 300 nm apamin, 10 μm CNQX, 50 μm APV, 10 μm SR95531 and 1 μm CGP55845. Baseline membrane potential was set at −60 mV by a continuous injection of −100 pA. The speed of the recording was reduced 100-fold at the beginning of the superfusion of XE991. (B) Summary plot showing the time-course of the effect of XE991 (n = 4). **P < 0.01; ***P < 0.001 vs. control.