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. Author manuscript; available in PMC: 2023 Oct 19.
Published in final edited form as: Clin Pharmacokinet. 2023 Aug 30;62(11):1567–1579. doi: 10.1007/s40262-023-01285-9

Table 3.

Percentages of simulation participants achieving 25(OH)D thresholds after 16 weeks of treatment.

Regimen Dosea Percent achieving 25(OH)D ≥ 40 ng/mL Percent achieving 25(OH)D ≥ 100 ng/mL Percent achieving 25(OH)D ≥ 150 ng/mL
1 50,000 IU loading + 10,000 IU daily 98 7 0
2 50,000 IU loading + 9,000 IU daily 93 2 0
3 50,000 IU loading + 8,000 IU daily 82 0 0
4 50,000 IU loading + 5,000 IU daily 66 0 0
5 8,000 IU daily dose 82 0 0
6 600 IU daily dose 0 0 0
a

The part 1 participants included in the final population PK model (N=44) were used in the simulation for each dosing regimen.