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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Neuropsychopharmacology. 2010 May 5;35(9):1897–1909. doi: 10.1038/npp.2010.61

Fig 4.

Fig 4

Greater NAS inhibition in neurons from 1- and 2-day FZP-withdrawn rats. Representative AMPAR-mediated mEPSCs (A, 1-day; D, 2-day) recorded before (solid line) and after (dotted line) external application of the potent spermine analogue, NAS (100 μM). The percent NAS inhibition of mEPSC current amplitude was increased (B, 1-day; E, 2-day) in CA1 neurons from FZP-withdrawn rats (p<0.05). Bath application of NAS abolished the increased AMPAR-mediated mEPSC amplitude in FZP-withdrawn neurons after 1-day (n= 7) and 2-days (n=12) and was without effect in control neurons (1-day, n= 6; 2-days, n=7), supporting the hypothesis that AMPAR current potentiation is mediated by synaptic incorporation of GluA2-lacking AMPARs. Asterisks denote * p≤.05 or ** p≤.01.