Table 1. mEPSC characteristics after postsynaptic application of CaMKII inhibitors.
Group (# cells) | RMP (mV) | Frequency (Hz) | Rise time (ms) | Amplitude (pA) | Decay tau (ms) | Conductance (pS) |
---|---|---|---|---|---|---|
CON | ||||||
+sAIP (n = 7) | -68.3 ± 1.0 | 0.23 ± 0.03 | 3.6 ± 0.3 | -8.5 ± 0.2 | 19.5 ± 1.6 | 8.6 ± 1.0 |
+ AIP (n = 6) | -66.0 ± 1.4 | 0.40 ± 0.09 | 2.9 ± 0.2 | -8.6 ± 0.3 | 18.2 ± 1.1 | 10.7 ± 0.9 |
+ACM (n = 7) | -65.6 ± 1.9 | 0.30 ± 0.09 | 3.0 ± 0.2 | -8.7 ± 0.2 | 17.8 ± 0.9 | 10.4 ± 0.4 |
FZP | ||||||
+sAIP (n = 7) | -64.7 ± 1.4 | 0.35 ± 0.10 | 3.0 ± 0.2 | -9.8 ± 0.2* | 17.0 ± 0.6 | 13.0 ± 1.0** |
+ AIP (n = 8) | -67.6 ± 1.9 | 0.37 ± 0.09 | 3.2 ± 0.2 | -8.6 ± 0.4† | 19.5 ± 1.5 | 9.6 ± 0.9 |
+ACM (n = 9) | -67.1 ± 2.3 | 0.27 ± 0.03 | 3.2 ± 0.1 | -9.3 ± 0.3 | 17.4 ± 1.4 | 10.8 ± 0.6 |
Values are listed as means ± S.E.M.
p<0.01;
p<0.05 (CON+sAIP vs. FZP+sAIP);
p<0.05 (FZP+sAIP vs. FZP+AIP)