Fig. 3 |. Age-dependent topic loadings of 10 inferred disease topics across 348 diseases in the UK Biobank.

We report topic loadings averaged across younger ages (age at diagnosis < 60) and older ages (age at diagnosis > 60). Row labels denote disease categories ordered by Phecode systems, with alternating blue and red color for visualization purposes; “Other” is a merge of five Phecode systems: “congenital anomalies”, “symptoms”, “injuries & poisoning”, “other tests”, and “death” (which is treated as an additional disease, see Methods). Topics are ordered by the corresponding Phecode system. Further details on the 10 topics are provided in Table 1. Further details on the diseases discussed in the text (type 2 diabetes and breast cancer) are provided in Extended Data Figure 2. Numerical results are reported in Supplementary Table 4.