Fig. 6 |. Polygenic risk scores vary across disease subtypes defined by distinct topics.

a, Stacked bar plots of age-dependent subtypes (defined by topics) for four representative diseases (type 2 diabetes, asthma, hypercholesterolemia, and essential hypertension); for each disease, we include all subtypes with at least one diagnosis. Results for all 52 diseases are reported in Supplementary Figure 16. b, Standardized excess PRS values in disease cases (s.d. increase in PRS per unit increase in patient topic weight) for four representative diseases and four corresponding topics. c, Relative risk for cases of type 2 diabetes and hypercholesterolemia of CVD and MGND subtypes (vs. controls) across PRS percentiles. Each point spans 2 PRS percentiles. Lines denote regression on log scale. Error bars denote 95% confidence intervals. Numerical results are reported in Supplementary Tables 11–13.