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. Author manuscript; available in PMC: 2023 Nov 10.
Published in final edited form as: Nat Genet. 2023 Oct 9;55(11):1854–1865. doi: 10.1038/s41588-023-01522-8

Extended Data Fig. 1. Plate notation of ATM generative model.

Extended Data Fig. 1.

M is the number of subjects; Ns is the number of records within sth subject. All plates (circles) are variables in the generative process, where the plates with shade w is the observed variable and plates without shade are unobserved variables to be inferred; is the topic weight; z is diagnosis-specific topic probability; t is the age at diagnosis for each diagnosis; is the topic loadings which are functions of age t; is the (non-informative) hyperparameter of the prior distribution of. The generative process is described in the Methods and Supplementary Note.