Table 3.
Annualized change in forced vital capacity for non-IPF ILD patients stratified by immunosuppression exposure and age-adjusted LTL above and below the 10th percentile of normal.
| Immunosuppression Exposed | Immunosuppression Unexposed | ||||
|---|---|---|---|---|---|
| N (N FVC) | Δ FVC, ml/year (95% CI)* | N (N FVC) | ΔFVC, ml/year (95% CI)* | P-value | |
| LTL <10th | 55 (209) | −141 (−218, −65) | 56 (177) | −111 (−184, −39) | 0.58 |
| LTL ≥10th | 231 (978) | −46 (−79, −12) | 195 (673) | −76 (−113, −39) | 0.23 |
*
Joint-model incorporating time-to-event and linear mixed-effects submodels, adjusted for ILD diagnosis, radiographic honeycombing, and ILD centre. Restricted to patients with ≥2 FVC measures while on immunosuppression within two-years of blood collection for exposed patients, and ≥2 FVC measures within two-years of blood collection for unexposed patients
Abbreviations: FVC, forced vital capacity, CI, confidence interval; LTL, leukocyte telomere length