Skip to main content
. Author manuscript; available in PMC: 2023 Dec 8.
Published in final edited form as: Cancer Immunol Immunother. 2023 Oct 17;72(12):3985–3999. doi: 10.1007/s00262-023-03530-3

Figure 3.

Figure 3.

CDIM/NR4A1 antagonists inhibit colon tumor growth in a syngeneic mouse model. C57BL/6 mice bearing MC-38 cells as xenografts were treated for 21 days with corn oil (control), DIM-3-Br-5-OCF3 (2.5 and 7.5 mg/kg/d), DIM-3,5-Cl2 (2.5 and 7.5 mg/kg/d) and effects on tumor volume (A, B), body weight changes (C) and tumor weights (D) were determined as outlined in the Methods. E. Tumor lysates from three animals per treatment group were analyzed by western blot as outlined in the Methods. Significant (p<0.05) changes in tumor volumes or weight and body weight are indicated.